We present a surface-based method for analyzing articular cartilage at the knee using clinical MRI data. This method offers several advantages over existing approaches, including the ability to visualize the spatial distribution of cartilage thickness and compositional parameters, and perform surface-based comparisons between individuals and within individuals over time using statistical parametric mapping. We outline the steps involved in the analysis pipeline and describe initial results in 5 human cadavers and 2 human subjects in vivo, demonstrating the promise of this technique.
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