In this study we examined ex-vivo bovine articular cartilage using quantitative susceptibility mapping (QSM). Our purpose was to find a reliable QSM measurement and estimation protocol and then study how different enzymatic and chemical degradations affect the susceptibility of articular cartilage, in order to establish the feasibility of QSM for the assessment of articular cartilage. Treatments by trypsin (to degrade proteoglycans) and EDTA (to remove calcifications) were found to have minimal effects on the susceptibility. However, a significant depth-wise anisotropy of susceptibility in cartilage was observed. Further studies are warranted to investigate the susceptibility changes in cartilage.