Measurement of bound water concentration in cortical bone with MRI is a promising method for evaluating bone fracture risk. One approach to measure bound water involves suppression of pore water signal with an adiabatic inversion-recovery pulse sequence. However, this approach requires a priori knowledge of pore water T1 which itself is expected to vary with bone porosity. We propose to minimize the effect of subject-dependent pore water T1 variation by in bound water imaging using a multiple adiabatic inversion recovery preparation optimized to suppress pore water over a broad T1 domain.
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