Low-magnitude mechanical stimulation (LMMS) has shown great potential as a non-pharmacological intervention for improving bone quality in animal models. However, human trials have yielded less compelling evidence, possibly related to difficulties in maintaining adherence and use of conventional imaging techniques not being able to detect subtle longitudinal changes. Here we investigated the use of high-resolution structural bone MRI in monitoring treatment efficacy of LMMS in postmenopausal women. The data show that baseline bone volume fraction at the distal tibia is associated with the changes observed over one year of active LMMS or placebo treatment.
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