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Abstract #1673

Non-invasive evaluation of functional and structural connectome changes in the mouse brain related to drug-induced neuro-modulation

Thomas Bienert1, Neele Hübner1, Anna Mechling1, Tanzil Mahmud Arefin1,2,3, Marco Reisert4, Máté Döbrössy5, Philipp Janz6, Carola Haas6, Laura Adela Harsan1,7,8, Jürgen Hennig4, Dominik von Elverfeldt1, and Karl Egger9

1Advanced Molecular Imaging Research (AMIR), Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 2Faculty of Biology, University of Freiburg, Freiburg, Germany, 3Department of Translational Medicine and Neurogenetics, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, Strasbourg, France, 4Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 5Division of Stereotactic and Functional Neurosurgery, Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, 6Experimental Epilepsy Research, Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, 7Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France, 8Laboratory of Engineering, Informatics and Imaging, University of Strasbourg, Strasbourg, France, 9Department of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany

Analysis of neuro-functional connectivity derived from rs-fMRI and neuro-structural connectivity derived from DTI/Fiber Tracking might enable researchers to monitor and characterize physiological or drug induced neuro-modulation in the mouse brain. In our study we present a framework for the analysis on healthy mice with erythropoietin (EPO) treatment. Brain regions with pronounced neuro-modulation in histology also showed changes in neuro-functional and neuro-structural data.

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Abstract