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Abstract #1679

Functional and Metabolic Connectivity of the Awake and Anesthetized Brain

Alan B McMillan1, Abigail Z Rajala2, Bethany J Stieve2, Rick L Jenison3, Rasmus M Birn4, and Luis C Populin2

1Radiology, University of Wisconsin, MADISON, WI, United States, 2Neuroscience, University of Wisconsin, MADISON, WI, United States, 3Psychology, University of Wisconsin, MADISON, WI, United States, 4Psychiatry, University of Wisconsin, MADISON, WI, United States

This study evaluated the effect of anesthesia on functional and metabolic brain connectivity, measured with simultaneous PET/MR using an awake monkey model. Results show a profound disruption of functional connectivity, effective connectivity, and novel approaches to metabolic connectivity following the administration of IV ketamine.

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