Functional connectivity of the thalamus could inform the potential efficacy of temporal resection in temporal lobe epilepsy. Diffusion and functional MRI was collected from 22 patients who underwent surgical treatment for temporal lobe epilepsy. The thalamus was segmented into six subregions based on diffusion tractography to six regions encompassing the entire cortex. Functional connectivity was calculated between each thalamic subregion and cortical region for each patient. Higher functional connectivity between the contralateral temporal-thalamic subregion and the cortex was associated with seizure recurrence after surgery.