Alcohol preferring and non-preferring rats were trained with two-bottle choice methods. The whole brain default mode network was acquired during different period of addiction training and after alcohol injection. The correlation coefficients among 28 regions were calculated by mean-value of Pearson correlation. The changes of brain connections after alcohol consumption in different stage of alcohol addiction is significant different. Furthermore, some addiction or reward associated regions and new possible areas (NAc, Tu, VTA, IC, Hypo, SNC, Au, DB, Hipp, VLPO, etc.) showed difference during the training. Our findings could provide preliminary functional connection support of neurobiological circuits change.
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