Cocaine applied in a “binge paradigm” induces a region-specific and persistent brain circuitry modulation.
Elisabeth Jonckers1, Michael Belloy1, Dany Dsouza2, Marleen Verhoye1, Thomas Mueggler2, and Annemie Van der Linden1
1Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium, 2Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland
Our pre-clinical rodent study showed an increased
Functional Connectivity at the level of the striatum and the cingulate cortex induced
by cocaine injection. The effect was detectable 4 hours after administering
cocaine and sustained for 24h.
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