Abstract #1707

Real-time fMRI functional connectivity self-regulation and motor performance

Patricia Vargas^1,2,3,4, Ranganatha Sitaram^1,2,3,5,6, Pradyumna Sepúlveda^3,4, Cristian Montalba⁴, Mohit Rana^1,2,3, Cristian Tejos^4,7, and Sergio Ruiz^1,2,3,5

¹Department of Psychiatry, Faculty of Medicine. Pontificia Universidad Católica de Chile, Santiago, Chile, ²Interdisciplinary Center for Neuroscience, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Laboratory for Brain Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁴Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁵Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany, ⁶Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁷Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Brain-Computer interfaces have been used for the rehabilitation of motor and cognitive functions. They can be used to train voluntary neural activity, leading to behavioral effects depending on the targeted brain areas.

The aim of this study was to test the feasibility of achieving volitional control of M1-cerebellum functional connectivity with a real-time fMRI (Rt-fMRI) system and evaluates its influence in motor performance.

Nine healthy subjects were trained in a protocol with visual feedback and motor imagery.

The results indicate that voluntary self-regulation of cerebellum-M1 connectivity is feasible with Rt-fMRI, but the effects on motor performance need to be further studied.

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