Altered Functional Connectivity in Essential Tremor Patients immediately following Thalamotomy using MRI guided Focused Ultrasound
Li Jiang1, Jiachen Zhuo1, Prashant Raghavan2, Dheeraj Gandhi2, Elias R. Melhem2, and Rao Gullapalli1
1Center for Metabolic Imaging & Therapeutics, Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore School of Medicine, Baltimore, MD, United States, 2Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore School of Medicine, Baltimore, MD, United States
Essential tremor (ET) is a common neurological disorder. It is often characterized by progressive tremor of the arms or hands during voluntary movements. Ablation of the ventralisintermedius nucleus (VIM) of thalamus appears to be an effective treatment for ET. However, little is known regarding changes in the brain networks among ET patients and even less regarding the network changes following the thalamotomy. This study used resting state fMRI to investigate the changes in functional connectivity (FC) in brain networks immediately after the thalamotomy and reveals reduced FC between the ablated VIM and the motor cortex and cerebellum.
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