In order to investigate gray matter cerebral blood flow (CBF) and CBF connectivity alterations in chronic stroke patients, 60 patients and 60 controls were recruited to undergo 3D ASL technique. The patients exhibited increased CBFs in contralesional SFG, thalamus and ITG, and decreased CBF in ipsilesional Post_CG. Further analysis showed decreased CBF connectivity in patients in ipsilesional Pre_CG, MFG and Msfg. Importantly, the patients exhibited disconnections between the SFG and MFG, mSFG, Pre_CG. Current results suggest that stroke-induced cognitive dysfunction may be a connectivity disorder from the perspective of CBF connectivity.