Diffusion-weighted imaging (DWI) has been proven that malignant orbital masses demonstrate significantly and visually appreciable lower apparent diffusion coefficient (ADC) than benign orbital masses[1-2]. Nevertheless, ADC cannot separate the pure molecular diffusion from the motion of water molecules in the capillary network; thus, perfusion contamination would increase the ADC value. According to the IVIM DWI model[3], both microscopic perfusion and diffusivity can be separated using a biexponential decay function, providing additional parameters for tissue characterization. From the result we can see that it is feasible that quantitative parameters of orbital masses can be derived from IVIM DWI.
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