Abstract #2241

Compulsivity as a Transdiagnostic Trait in Humans and Animal Models

Muriel M. K. Bruchhage¹, Ilse van Ooijen–van de Vondervoort², Erwin L. A. Blezer³, Katarzyna Kapusta², Houshang Amiri², David J. Lythgoe¹, Marcel P. Zwiers⁴, Rick M. Dijkhuizen⁵, Jeffrey C. Glennon², Sarah Durston⁵, Daniel Brandeis⁶, Jan Buitelaar⁴, Steven C. R. Williams¹, and Flavio Dell'Acqua⁷

¹Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ²Department of Cognitive Neurscience, Radboud University Medical Center, Nijmegen, Netherlands, ³Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands, ⁵Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health Mannheim, Mannheim, Germany, ⁷NatBrainLab, Department of Forensics and Neurodevelopmental Sciences, Sackler Institute of Translational Neuroimaging, King's College London, London, United Kingdom

Obsessive-compulsive disorder (OCD) and diabetes mellitus type 2 (DM2) show compulsive behaviour1 and share genetic vulnerability2. Using Diffusion Tensor Imaging as a translational approach, we investigated differences in corpus callosum (CC) body white matter microstructure in a paediatric human OCD cohort and juvenile animal models for OCD and DM2. In all three groups, fractional anisotropy increased in the CC body compared to controls, which correlated with increasing compulsive behaviour. This was coupled with a decrease in CC mean diffusivity in the animal models. Our results underline the importance of compulsive behaviour as a possible trans-diagnostic trait across OCD and DM2.

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