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Abstract #2493

Comparison of MR spectroscopic imaging findings between different MAPT and COMT genotypes of cognitively normal or mild cognitively impaired Parkinson’s disease patients at 3T

Sevim Cengiz1, Ani Kicik2,3, Emel Erdogdu4, Dilek Betul Arslan1, Seda Buker5, Zeynep Tufekcioglu5, Aziz Mufit Ulug1,6, Basar Bilgic5, Hakan Gurvit5, Tamer Demiralp2,7, Erdem Tuzun8, Hasmet Hanagasi5, and Esin Ozturk-Isik1

1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Hulusi Behcet Life Sciences Research Laboratory, Istanbul University, Istanbul, Turkey, 3Istanbul University, Institute of Experimental Medicine, Department of Neuroscience, Istanbul, Turkey, 4Institute of Psychology and Cognition Research, University of Bremen, Germany, 5Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 6CorTechs Labs, San Diego, CA, USA, 7Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 8Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

Microtubule-associated protein tau (MAPT) and catechol-O-methyltransferase (COMT) genotypes have been associated with cognitive impairment in Parkinson’s disease (PD). The aim of this study is to compare MR spectroscopic imaging findings between cognitively normal PD (PD-CN) or mild cognitively impaired PD (PD-MCI) patients with different MAPT and COMT genotypes at 3T. We observed a higher Ins/Cr in cerebral white matter of PD-MCI with MAPT H1/H2 genotype than PD-CN with MAPT H1/H1 genotype and a higher Cho/Cr in thalamus of PD-MCI with COMT Met/Met genotype and PD-CN with COMT Val/Val or Val/Met genotype than PD-CN with COMT Met/Met genotype.

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Abstract