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Abstract #2494

Preliminary findings of elevated iron deposition in the substantia nigra in patients with idiopathic Parkinson’s disease using a high iron content evaluation of quantitative susceptibility mapping

Sean K Sethi1, Shawn Kisch2, Kiarash Ghassaban1, Saifeng Liu3, Miller Fawaz1, Ali H. Rajput4, Alex Rajput4, Paul Babyn5, Peter Szkup5, and E. Mark Haacke1,3,6

1Research, Magnetic Resonance Innovations, Inc., Detroit, MI, United States, 2Department of Medical Imaging, Saskatoon Health Region, 3Research, The MRI Institute for Biomedical Research, Detroit, MI, United States, 4Division of Neurology in the Department of Medicine, University of Saskatchewan, 5Department of Medical Imaging, University of Saskatchewan, Saskatoon, SK, 6Radiology, Wayne State University School of Medicine

Iron deposition in the brain has been implicated in neurodegenerative diseases like Parkinson’s Disease. We used quantitative susceptibility mapping to evaluate iron content in the substantia nigra and red nucleus in 18 patients with idiopathic Parkinson’s Disease (IPD). Susceptibility was calculated for whole structure and a thresholded high-iron region (RII) and compared with controls. We found that global and RII mean susceptibility higher in the substantia nigra compared with normals, and that the slope of RII susceptibility vs age is higher in IPD compared to normals which may suggest an increased rate of iron deposition at disease onset.

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