Aim of this study was to identify the MRI predictors of medium-term disability and cognitive impairment accrual in patients with the main clinical phenotypes of multiple sclerosis (MS). Results indicated that clinical disability and cognitive impairment at follow-up were predicted by measures of structural and microstructural damage, as well as by resting state functional connectivity measures. Preserved white matter integrity predicted clinical improvement. Grey matter involvement played a critical role in MS-related clinical worsening and evolution to a more severe disease phenotype.
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