Nicotinic acid and isonicotinic acid are two derivatives of pyridine carboxylic acids. Both substrates are of high interest in medical chemistry. In the current study seven fluorinated derivatives of these pyridine carboxylic acids were chosen for examination of the 1H and 19F hyperpolarizability using the SABRE technique. Influences of the position of the carboxylic group and fluorine as well as the catalyst system concerning the achievable signal enhancements were examined. Furthermore an H/D-exchange could be observed in some cases. The presented data gives important information for future MR imaging studies.