Whole-Tumor Quantitative Apparent Diffusion Coefficient Histogram and Texture Analysis to Differentiation of Minimal Fat Angiomyolipoma from Clear Cell Renal Cell Carcinoma

The purpose of this study was to determine whether whole-tumor ADC histogram and texture analysis is helpful for distinguishing MFAML from ccRCC. The differences of ADC histogram and texture parameters between MFAML and ccRCC were compared using the independent-sample t test. There were significant differences on ADCmean, ADCmedian, ADC25%, ADC75%, ADC90% and skewness between MFAML and ccRCC. The ADC90% derived from the whole-tumor ADC histogram analysis showed the best diagnostic value in discriminating MFAML and ccRCC. Therefore, whole-tumor ADC histogram and texture parameters can be used as a quantitative tool to distinguish MFAML from ccRCC.