The purpose of this study was to determine whether whole-tumor ADC histogram and texture analysis is helpful for distinguishing MFAML from ccRCC. The differences of ADC histogram and texture parameters between MFAML and ccRCC were compared using the independent-sample t test. There were significant differences on ADCmean, ADCmedian, ADC25%, ADC75%, ADC90% and skewness between MFAML and ccRCC. The ADC90% derived from the whole-tumor ADC histogram analysis showed the best diagnostic value in discriminating MFAML and ccRCC. Therefore, whole-tumor ADC histogram and texture parameters can be used as a quantitative tool to distinguish MFAML from ccRCC.