Abstract #3430

Detection of Brown Adipose Tissue: Hyperpolarized 129Xe MRI vs Xenon Enhanced CT

Rosa Tamara Branca^1,2, Andrew McCallister^1,2, Hong Yuan², Le Zhang^2,3, Alex Burant^1,2, and Michael Antonacci^1,2

¹Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Material Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Despite histological evidence that all humans have brown adipose tissue, the detection of this tissue in overweight and obese subjects has proven to be a challenge. Here we demonstrate the combined used of hyperpolarized xenon gas (HP129Xe) MRI and xenon enhanced CT for the detection of BAT thermogenic activity and mass in lean and obese mouse phenotypes as well as our preliminary results in healthy young volunteers.

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