Improvement of sensitivity and specificity in DWI-based assessment of nodal diseases is dependent on a better understanding of how nodal microstructures affect the water diffusivity in tissue. In this abstract we report the first diffusion microimaging investigation of formalin fixed node tissue with the aim of assessing any correlation between mean diffusivity and cellularity. Mean diffusivity was calculated in ROI corresponding to distinct node sub-structures. Nuclei were segmented semi-automatically to measure the cellularity metrics: nuclear count and nuclear area. The results showed there is no significant correlation between mean diffusivity with cellularity metrics in the nodal tissues.