The purpose of our study was to investigate the relationship between splenic MR elastography (MRE) and liver fibrosis stages. 109 patients underwent histological examination and abdominal MR examination within 3-months interval were enrolled in our study. MRE was performed with passive driver on right and left chest wall separately. The mean stiffness value of liver and spleen was determined and showed good correlation between hepatic/splenic stiffness and liver fibrosis stage. Our results demonstrated that spleen stiffness measured by MRE was significant correlated with liver fibrosis stage. Combination of the spleen/liver stiffness provide higher diagnostic value than liver stiffness alone.