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Abstract #3568

A Transgenic Method to Enhance Intracellular Retention of Iron Oxide Nanoparticles and Prolong MRI Tracking

Xiaoyong Zhang1, Ximei Qian2, Sha Wang1, and Xiaoping Hu1

1Bourns college of engineering, University of California, ´╗┐Riverside, CA, United States, 2Department of Biomedical Engineering, Emory University

Iron oxide nanoparticles (IONPs) are widely used as labels for noninvasive cell tracking using magnetic resonance imaging (MRI). However, IONP induced contrast dilutes rapidly over time due to cell growth and division, limiting its applications in long-term cellular visualization. In the present work, unlike techniques focusing on modification of IONPs, we established a novel transgenic approach to increase IONP retention, significantly prolonging the tracking time of IONP labeled cells. In addition, this approach could be generalized to other cell types and magnetic nanoparticles, making it attractive for long-term cell tracking or tumor progression monitoring.

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