Multiple Instantaneous Switchable Scans (MISS) is a type of interleaved scan method. In our study of prostate MRI, we combined the 3D-T2W and DWI by MISS into one scan, both of which are essential sequences for PIRADS v2. The combined sequences improved the scan efficiency (6min to 4min30s). The image quality and lesion display of MISS is similar to conventional T2W and DWI. The 3D-T2W in MISS showed better performance of seminal vesicles and lesion contrast and allowed for interactive multiplanar reformation.