Abstract #3890

PET-MRI in hepatocellular carcinoma: Correlation of DCE-MRI perfusion quantification using shutter-speed model with FDG uptake

Stefanie Hectors¹, Mathilde Wagner¹, Cecilia Besa¹, Wei Huang², and Bachir Taouli¹

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States

Shutter-speed modeling (SSM) of DCE-MRI data allows for estimation of the mean intracellular water molecular lifetime (τ_i), which has been suggested to be associated with tissue metabolic activity. In this study, we assessed the correlation between SSM DCE-MRI parameters and FDG-PET uptake in hepatocellular carcinoma (HCC) lesions. While K^trans did show a significant negative correlation with the standardized uptake value (SUV) in the HCC lesions, τ_i was not significantly associated with FDG uptake. Our preliminary findings suggest that τi may not be associated with the up-stream tumor glucose metabolism as measured by FDG-PET.

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