Several different neural systems are likely to be dysregulated to promote maladaptive behaviors associated with drug addiction. Here, we investigate changes in global functional connectivity across the brain following self-administration of cocaine and a period of abstinence in rats. We found whole brain enhancement in synchronized activity immediately following cocaine self-administration compared to pre-cocaine. Furthermore, whole brain network connectivity continued to strengthen following a period of abstinence. These data suggest that the dynamic shifts in functional connectivity following cocaine exposure persist during periods of abstinence and may provide a critical mechanistic link to relapse susceptibility.