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Abstract #4092

Imaging of glutamate alterations in a mouse model of temporal lobe epilepsy

Niels Leonard Schwaderlapp1, Philipp Janz2, Jochen Leupold1, Dominik von Elverfeldt1, Jan Korvink3, J├╝rgen Hennig1, Carola Haas2, and Pierre LeVan1

1Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2Dept. of Neurosurgery, Experimental Epilepsy, University Medical Center Freiburg, 3Institute of Microstructure Technology, Karlsruhe Institute of Technology

Hippocampal sclerosis involves neuronal loss in hippocampal subfields and is a common characteristic of temporal lobe epilepsy (TLE). Investigation of the metabolic alterations following a status epilepticus may lead to a better understanding of epileptogenesis and can reveal biomarkers for TLE. Overcoming the major disadvantages of single voxel 1H MR spectroscopy, namely a low spatial and temporal resolution, this study investigates the capability of the glutamate chemical exchange saturation transfer (GluCEST) method to map endogenous glutamate alterations in a mouse model of TLE.

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