Graph theory analysis is a method recently introduced to study the brain as a network. In this study we investigate the topological distribution of the speech and language functional network in nfvPPA patients characterized by isolated and progressive language impairments. We identified the hubs of the speech and language network in healthy controls and nfvPPA. In patients, the network presented an abnormal topological distribution where right-sided brain regions were recruited. These findings suggest that in nfvPPA this network reorganizes in the presence of localized gray matter volume loss.