Neurite orientation dispersion and density imaging (NODDI) was an advanced DWI. Our study is to quantitatively evaluate the diagnostic efficiency of NODDI in grading gliomas. 29 patients were recruited and they underwent whole-brain DWI which were collected at three b value (0, 1000 and 2000 s/mm2) and 1000 and 2000 s/mm2 with 30 directions. Compared with LGG, ficvf and ODI are significantly higher in HGG and the mean value of ficvf showed the highest diagnostic value. Quantitative parameters from NODDI can aid in gliomas grading and the mean value of ficvf showed the highest diagnostic power.