DKI is a promising tool to predict the survival of glioma patients. MK, MD and ADC were significantly correlated with overall survival (OS) of patients with astrocytic tumor. By univariate Kaplan-Meier survival analyses, OS of the patients was related to tumor grade, Ki-67 LI, resection status, enhancement degree, edge, edema degree, lesion number, MK, MD and ADC (log rank p < 0.05 for all). Multivariate Cox regression analysis indicated that MK is an independent predictor of OS in these patients, and it is a risk factor (P = 0.006, HR=2.142 and 95%CI=1.247-3.679 for MK increasing every 0.1). These results are helpful to clinic.