Diffusion MRI can be helpful in pre-operative brain tumor evaluation to assess white matter tracts involved. It is however a time-consuming sequence, a problem that Simultaneous Multi-slice Imaging was designed to solve, although it has to demonstrate its quality non-inferiority. We compared in five patients tractographic data (using HARDI), acquired with and without SMS techniques, to evaluate the quality of imaging data as measured by the number of fibers between two regions of interest. We found that SMS-factor 2, cut time down by 37%, which is clinically relevant. We also found that SMS-2 is indeed non-inferior (alpha=0,03125) and can be used without quality compromise.