Abstract #4273

Age Related Differences in the geomT2 Relaxation Assessed Using Multi-Echo T2 Imaging

Muzamil Arshad^1,2, Jeffrey A. Stanley¹, and Naftali Raz^3,4

¹Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, ²MD/PhD Program, Wayne State University School of Medicine, Detroit, MI, United States, ³Psychology, Wayne State University, ⁴Institute of Gerontology, Wayne State University

Multi-echo T₂ imaging (ME-T₂) enables the investigation of multiple white matter compartments. The short T₂ compartment has been the focus of recent investigations due to its specificity for the myelin water compartment. However, the much larger intra/extra cellular (IE) compartment has been relatively less explored. Here we investigate age differences in the geometric mean T₂ (geomT_2IEW) of the IE compartment in subcortical white matter tracts. We demonstrate that the effects of age on geomT_2IEW are not uniform across white matter tracts and suggest that this index may offer additional value in the characterization of age differences of white matter microstructure.

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