In this study, in vivo quantification of brain metabolites measured on the dorsolateral prefrontal cortex (DLPFC) was carried out with LCModel using a priori knowledge based on experiment metabolite basis set signals. The main observation in this work was the significant reduction of tCho and Ins, and increase of GSH and Glx concentrations in the left DLPFC of alcohol dependent patients compared to healthy control subjects.
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