Abstract #4391

Distortion-Free Diffusion MRI using an MRI-Guided Tri-Cobalt 60 Radiotherapy System: Sequence Validation and Preliminary Clinical Experience

Yu Gao^1,2, Minsong Cao^2,3, Tania Kaprealian³, Mitchell Kamrava³, Michael Wang³, John Neylon³, Daniel Low^2,3, Yingli Yang^2,3, and Peng Hu^1,2

¹Radiology, University of California, Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States, ³Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States

Limited resolution, severe distortion, and inaccurate quantification in low SNR scenarios associated with the conventional DW-ssEPI are problematic for adaptive radiotherapy based on tumor response. In this study, we sought to develop a reliable, accurate and distortion-free diffusion sequence that is practicable for longitudinal assessment of tumor response using an MRI-guided radiotherapy system. Quantitative phantom studies validated the superiority of the proposed technique over standard DW-ssEPI in terms of geometric fidelity and ADC accuracy. Excellent ADC reproducibility makes it a promising candidate for tumor response monitoring. Preliminary patient study demonstrated its feasibility to be used for tumor response assessment.

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