Abstract #4392

Proton Magnetic Resonance Spectroscopy of the Lipid Metabolic Response of a Murine Tumor Model to Radiation Therapy

Anthony G. Tessier¹, Atiyah Yahya^1,2, Matthew Larocque^1,2, B. Gino Fallone^1,2, and Alasdair Syme^3,4

¹Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada, ²Oncology, University of Alberta, Edmonton, AB, Canada, ³Radiation Oncology, Dalhousie University, Halifax, NS, Canada, ⁴Medical Physics, QEII Health Sciences Centre, Nova Scotia Health Authority, Halifax, NS, Canada

The temporal dependence of the lipid metabolic response to single fraction radiation therapy of human glioblastoma multiforme xenografts in NIH III nude mice was assessed with in vivo ¹H magnetic resonance spectroscopy (MRS) on a 9.4T magnetic resonance system. Lipid MRS can measure fat polyunsaturation, and therapeutic response can be monitored. The methylene:methyl peak ratio (CH₂/CH₃) can assess drug treatment and disease progression. Herein, lipid parameters and their response to radiotherapy in tumors are studied, including methyl, lactate + methylene, diallylic, and allylic protons, protons in α position to the carbonyl group, CH₂/CH₃, and mean polyunsaturation.

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