Abstract #4513

Decreased apparent fibre density in an experimental model of traumatic brain injury

David K Wright^1,2, Leigh A Johnston^2,3, Jeff Kershaw⁴, Roger Ordidge⁵, Terence J O'Brien⁶, and Sandy R Shultz⁶

¹Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Australia, ²The Florey Institute of Neuroscience and Mental Health, Parkville, Australia, ³Department of Electrical & Electronic Engineering, The University of Melbourne, Australia, ⁴National Institute of Radiological Sciences, Japan, ⁵Department of Anatomy and Neuroscience, The University of Melbourne, Australia, ⁶Department of Medicine, The University of Melbourne, Australia

Apparent fibre density (AFD) is postulated to be a sensitive marker of white matter damage and, as it is derived from a continuous fibre orientation distribution, may identify changes along single fibre bundles in regions containing multiple fibre groups. Here, we compared AFD to traditional DTI metrics in an experimental model of traumatic brain injury (TBI). We found that rats given a TBI had widespread regions of reduced AFD when compared to sham-injured rats as well as significant, but less extensive changes in DTI metrics. These results support the use of AFD in assessing disease progression and treatment following TBI.

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