Adolescents who sustained a concussion and had persistent symptoms were scanned with DSC-PWI, to assess blood flow, and DTI. Images were compared with controls using automatically defined ROIs by registration to an atlas, and manually drawing ROIs. While both techniques showed similar trends manual ROIs has less variance within groups and therefore greater sensitivity. To detect subtle imaging changes after concussion on an individual basis, manual ROIs, despite being time intensive to define, should still be considered due to their greater sensitivity.
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