Abstract #4532

Measurements of Microstructural Changes after Sildenafil Treatment of Experimental Traumatic Brain Injury in Rats using Diffusion Tensor Imaging

Asamoah Bosomtwi^1,2, Alexandru Korotcov^1,2, Angela Pronger³, Margalit Haber¹, Andrew Hoy^2,3, Ramon Diaz-Arrastia^3,4, and Bernard J Dardzinski^2,3

¹Center for Neuroscience and Regenerative Medicine, Henry Jackson Foundation, Bethesda, MD, United States, ²Radiology and Radiological Sciences, Uniformed Services University of Health Sciences, Bethesda, MD, United States, ³Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Bethesda, MD, United States, ⁴Neurology, Uniformed Services University of Health Sciences, Bethesda, MD, United States

The long-term dynamic response of microstructural changes in rat brain to the administration of sildenafil after traumatic brain injury (TBI) using non-invasive MRI techniques have been investigated. Our results demonstrate that the treatment of diffuse traumatic brain injury with sildenafil reverses several changes in brain microstructure at 30 days post injury. Diffusion tensor imaging (DTI) data suggests that sildenafil treatment improves white matter reorganization after TBI in rats compared with saline treatment.

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