Despite consensus guidelines advising volumetric analysis of tumours over single slice region-of-interest analysis, there is little data in the literature to support this recommendation. In this study we compare the reproducibility between each of these two methods in 20 patients with prostate cancer and also determine the intraobserver repeatability of each method. We show high levels of agreement and intraobserver repeatability in both of these methods. This study suggests that region-of-interest analysis is a perfectly acceptable analytical method and may have higher intraoberver repeatability than volumetric analysis, and could expedite the analysis of multiparametric prostate MRI datasets in clinical trials.
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