Abstract #4796

Quantitatively Differentiating Prostate Cancer, Prostatitis and Benign Prostatic Hyperplasia (BPH) by Diffusion MRI Histology (D-Histo)

Ze-Zhong Ye¹, Qingsong Yang ², Peng Sun ³, Yasheng Zhu⁴, Chunyu Song⁵, Joshua Lin⁶, Jianping Lu², Yinghao Sun⁴, and Sheng-Kwei Song^3,5,7

¹Chemistry, Washington University, St. Louis, MO, United States, ²Radiology, Changhai Hospital, Shanghai, People's Republic of China, ³Radiology, Washington University, St. Louis, MO, United States, ⁴Urology, Changhai Hospital, Shanghai, People's Republic of China, ⁵Biomedical Engineering, Washington University, St. Louis, MO, United States, ⁶Biology, Washington University, St. Louis, MO, United States, ⁷Hope Center for Neurological Disorder, Washington University, St. Louis, MO, United States

A recent consensus established mpMRI for PCa detection has not had the needed sensitivity or specificity to distinguish prostatitis from PCa. Thus, PCa diagnosis by MRI remains uncertain, resulting in over-diagnosis and over-treatment. For the first time, we demonstrate that the new method, diffusion MRI histology (D-Histo), accurately localizes and quantifies PCa, prostatitis, and BPH. With improved diagnosis accuracy, D-Histo affords effective guidance of treatment planning, and assessment of treatment efficacy.

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