Ureteropelvic junction obstruction constitutes a major cause of progressive pediatric renal disease. To date the follow-up of patients is difficult because there is a lack of non-invasive biomarkers. Here we propose to quantitatively characterize impairment of the kidney parenchyma after partial unilateral ureteral obstruction (pUUO) on mice using an intravoxel incoherent motion diffusion sequence. The results suggest that an f reduction is associated with a decrease in the volume of the renal parenchyma, which could be related to decreased renal vascularization. The later may occur before impairment by fibrosis and the findings are in accordance with the literature on pUUO.