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Abstract #4887

Gadobutrol- vs. gadoterate meglumine-enhanced multi-phase 3D-MRA and 4D-MRA at 1.5T and 3T: an intra-individual quantitative and qualitative comparison of macrocyclic contrast agents in minipigs

Dariusch Reza Hadizadeh1, Gregor Jost2, Vera Catharina Keil1, Christian Marx1, Maximilian Rauch1, Frederic Carsten Schmeel1, Hubertus Pietsch2, Hans Heinz Schild1, and Winfried Albert Willinek3

1Radiology, University of Bonn, Bonn, Germany, 2MR and CT Contrast Media Research, Bayer Pharma AG, Berlin, Germany, 3Zentrum für Radiologie, Neuroradiologie, Sonographie und Nuklearmedizin, Krankenhaus der barmherzigen Brüder, Trier, Germany

In an animal model bolus kinetics and image quality of the macrocyclic contrast agents (CA) gadobutrol (standard and half-dose) and gadoterate meglumine (standard-dose) were investigated intra-individually in multi-phase 3D- (MP3D) MRA and in 4D-MRA at 1.5T and 3T. Standard dose gadobutrol provided significantly higher signals in both MP3D- and 4D-MRA at both field strengths. Differences were most prominent in venous imaging phases. At 3T, arterial first pass peaks were truncated in 7/8 minipigs using standard dose CA. Image quality analysis of MP3D confirmed higher image quality in venous phases with standard-dose gadobutrol compared to gadoterate meglumine at both field strengths.

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