Apparent Diffusion Coefficient (ADC) maps obtained diffusion weighted imaging (DWI) have been shown to detect prostate cancer (PCa) and also correlate with tumor aggressiveness. Recent studies showed that improve detection of prostate cancer by high b-value DWI. However, high b-value images have an inherently low signal-to-noise ratio (SNR) and are prone to increased susceptibility artefact. Computed DWI (cDWI) is a method capable of obtaining high b-value images, which avoids the technical challenges of actually measuring them. Previous studies with limited sample size have evaluated the cDWI with high b-value but results were not conclusive. Current study may give an insight whether high b-value cDWI is valuable for differentiation of high risk versus low risk PCa.
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