Abstract #5089

Knee cartilage T2 mapping with T2-prepared isotropic 3D GRE has equivalent precision and higher accuracy compared to multi-slice TSE in volunteers and patients at 3T

Roberto Colotti¹, Patrick Omoumi¹, Gabriele Bonanno^1,2,3, Jean-Baptiste Ledoux¹, and Ruud B. van Heeswijk¹

¹Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ²Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, United States, ³Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, United States

The goal of this study was to compare the precision and accuracy of a novel isotropic 3D T₂-prepared gradient-echo T₂ mapping technique (Iso3DGRE) with the clinical standard 2D multi-slice turbo spin-echo (MS-TSE) for T₂ mapping of knee cartilage at 3T. A phantom study was performed to determine the accuracy of both techniques against the reference standard spin echo (SE). T₂ mapping of knee cartilage was then performed in 13 healthy volunteers and 5 patients with late-stage osteoarthritis. Compared to MS-TSE, Iso3DGRE T₂ mapping resulted in T₂ values with equivalent precision and slightly higher accuracy at a higher spatial resolution.

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