We compared the potential of various diffusion parameters obtained from Gaussian and non-Gaussian diffusion models in differentiating focal lesions of malignant spinal tumors. Mean signal intensity was calculated by placing ROIs within focal lesions for 9 b-values in each subject. ADC, frac<1, frac>3, and PG(D) differed significantly between focal lesions of myeloma and LCA. Frac>3 and PG(D) was significantly different between focal lesions of myeloma and MMK. Non-Gaussian diffusion parameters may provide additional information and improve the differentiation of malignant focal lesions compared with conventional diffusion parameters, which would be helpful in improving therapy strategies.