Abstract #5140

Q-space imaging is a novel technique to evaluate intervertebral disc degeneration.

Daisuke Nakashima¹, Nobuyuki Fujita¹, Junichi Hata^2,3, Takeo Nagura¹, Kanehiro Fujiyoshi⁴, Hideyuki Okano^2,3, Masahiro Jinzaki⁵, Morio Matsumoto¹, and Masaya Nakamura¹

¹Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, ²Department of Physiology, Keio University School of Medicine, Tokyo, Japan, ³Central Institute for Experimental Animals, Kawasaki, Japan, ⁴Department of Orthopaedic Surgery, Murayama Medical Center, Japan, ⁵Department of Radiology, Keio University School of Medicine, Tokyo, Japan

Pfirrmann classification on T2WI has been the qualitative grading of intervertebral disc (IVD) degeneration which is difficult to classify subtle changes of degeneration. A quantitative and more sensitive classification system has been sought.

In this research, probability at zero displacement obtained from Q-space imaging (QSI) which is a quantitative diffusion-weighted MRI procedure made it possible to observe the effect of the regenerative antioxidant drug: N-Acetyl Cystaine on IVD degeneration which could not be observed by using T2 mapping.

Probability at zero displacement obtained from QSI has the possibility to be a novel biomarker of IVD degeneration.

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