Areas across the visual cortex are functionally connected. A stressful striped pattern induces perceptual illusions/distortions and visual discomfort in most people, headaches in patients with migraine, and seizures in patients with photosensitive epilepsy. In contrary, a non-stressful striped pattern does not induce such effects. This study found that a 25-min visual stimulation showed a significantly contrary effect of the stressful vs. non-stressful striped patterns on human visual cortical functional connectivity (FC). To the contrary of the strengthening effect of the stressful striped pattern on the FC, the non-stressful striped pattern showed a weakening effect on the FC.