Purpose: To investigate the impact of prior episodes of hepatic encephalopathy (HE) on post-transplantation brain function recovery. Method: Thirty-three cirrhotic patients (HE, n=15 and noHE, n=18) and 30 healthy controls were included. Functional connectivity strength (FCS) were compared between the pre-LT data and the post-LT data, respectively. Results: For the noHE group, the altered FCS found pre-LT largely returned to nearly normal levels soon after LT. The abnormal FCS prior to LT was largely preserved in the HE group, including high-level cognition-related and vision-related areas. Conclusion: Pre-LT episode of HE may have adverse effects on post-LT brain function recovery.
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