Abstract #0047

Mechanisms underlying negative fMRI response in the striatum

Domenic H. Cerri¹, Daniel Albaugh ¹, Brittany Katz¹, SungHo Lee¹, Weiting Zhang¹, Lindsay Walton², Martin MacKinnon¹, Esteban Oyarzabal¹, Heather Decot¹, Nathalie Van Den Berge¹, Chunxiu Yu³, Colleen Mills-Finnerty⁴, Warren Grill³, Amit Etkin⁴, Guohong Cui⁵, Garret Stuber⁶, and Yen-Yu Ian Shih¹

¹Neurology & Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Duke University, Durham, NC, United States, ⁴Stanford University, Stanford, CA, United States, ⁵National Institute of Environmental Health Sciences, Durham, NC, United States, ⁶Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Optogenetic stimulation of striatal neurons and several afferents evoke robust negative fMRI responses in the striatum, while striatal electrophysiological recordings during the same stimulations show increases in neuronal activity. Pharmacological manipulations during D1MSN-induced negative striatal responses suggest responses are downstream of MSN activity, but not interneurons or local DA release. Fiber-photometry data from D2MSNs shows a similar pattern of neurovascular uncoupling/negative coupling. This negative fMRI response is also apparent in the human brain. Our results indicate that positive BOLD in the striatum is mediated through DA release, and that negative BOLD in the striatum is induced by local neuronal activations.

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