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Abstract #0097

ACRIN 6702 Multisite Breast DWI Trial: Comparison of Site vs. Centralized ADC Measures and Factors Affecting Data Quality

Savannah C Partridge1, Zheng Zhang2, Jennifer Whisenant3, Averi E Kitsch1, Justin Romanoff2, Habib Rahbar1, Thomas Yankeelov4, and Thomas L Chenevert5

1Radiology, University of Washington, Seattle, WA, United States, 2ACRIN Biostatistics Center, Brown University, Providence, RI, United States, 3Hematology/Oncology, Vanderbilt University, Nashville, TN, United States, 4Biomedical Engineering, University of Texas, Austin, TX, United States, 5Radiology, University of Michigan, Ann Arbor, MI, United States

Diffusion-weighted imaging (DWI) shows potential to improve lesion characterization and diagnostic performance of conventional contrast-enhanced breast MRI. Promising preliminary data from the ACRIN 6702 multisite trial show that DWI can reduce false-positive breast MRIs. Comparison of independently performed site and centrally-measured ADC values showed reasonable agreement, but suggest that further standardization of DWI interpretation and analysis tools across sites could improve diagnostic performance. Results also show more work is needed to address image quality issues and increase utility for measuring ADC values in MRI-detected breast lesions.

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